This cPanel webmail error was caused of by bug reported in http://bugs.horde.org/ticket/?id=4070 decided to hit one of our customer’s client accounts. Customer had old cPanel version and don’t want to upgrade due to internal reasons. Client said, he was exploring the Horde’s vast options (Horde is a web Outlook – can’t complain :D) and while messing up with the Layout options in Horde he hit the bug,
Fatal error: Cannot use string offset as an array in /usr/local/cpanel/base/horde/lib/Horde/Block/Layout/Manager.php on line 389
Not sure what caused the issue and it is not happening with IE, and only in FF. However a simple layout reset fixed the issue. Good Luck. Still, we need to find the real cause.